The Kunming-Montreal Global Biodiversity Framework calls for the conservation of 30% of the world’s ecosystems and the reduction of invasive species introductions and impacts by identifying and managing introduction pathways and preventing the introduction and establishment of priority invasive alien species. While protected areas have historically limited the introduction and spread of non-native species, climate change is expected to increase their susceptibility to invasions. However, our understanding how climate change may alter pathways into protected areas remains incomplete. This presentation will explore how climate change may impact introduction pathways in terrestrial, freshwater, marine, and island ecosystems and present a climate-smart approach to biosecurity which includes the incorporation of new tools and technologies (horizon scanning, hotspot analysis, network analysis, culturomics) and integrated planning through risk analyses and scenario planning. Additionally, It will present the information on an ongoing horizon scan to identify range shifting forest pests as an example of how we can better inform invasive species management and prevention in a changing world.